网站公告: 实验室管理系统入口---- 个人信息填写流程---- 新闻发布流程
您当前所在位置: 首页  >  成果展示  >  发表论文  >  2022年

Genomic innovation and regulatory rewiring during evolution of the cotton genus Gossypium

更新时间:2022-12-07 10:26:59点击次数:字号:T|T

Abstract

Phenotypic diversity and evolutionary innovation ultimately trace to variation in genomic sequence and rewiring of regulatory networks. Here, we constructed a pan-genome of the Gossypium genus using ten representative diploid genomes. We document the genomic evolutionary history and the impact of lineage-specific transposon amplification on differential genome composition. The pan-3D genome reveals evolutionary connections between transposon-driven genome size variation and both higher-order chromatin structure reorganization and the rewiring of chromatin interactome. We linked changes in chromatin structures to phenotypic differences in cotton fiber and identified regulatory variations that decode the genetic basis of fiber length, the latter enabled by sequencing 1,005 transcriptomes during fiber development. We showcase how pan-genomic, pan-3D genomic and genetic regulatory data serve as a resource for delineating the evolutionary basis of spinnable cotton fiber. Our work provides insights into the evolution of genome organization and regulation and will inform cotton improvement by enabling regulome-based approaches.


full text:https://www.nature.com/articles/s41588-022-01237-2